THE TRANSFER OF ANDROGENS IN PARABIOTIC RATS

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Abstract
Observations were made on 55 castrated [male]-[male] parabiotic rats, 27 single castrated [male] rats treated with varying amts. of testosterone propionate, 7 untreated single castrated [male] rats, and 8 single normal [male] rate. The parabiotics were littermate rats weighing 70 g. or more, united at 31-33 days of age, at which time both were castrated. Injns. were made once daily for 10 days. One partner of the parabiotic rats was injd. with doses of testosterone propionate varying between 15 and 1000 [gamma]. Evidence of transfer of the androgen from the injd. to the uninjd. parabiont, as based on an increase in wt. of seminal vesicles and prostate, was found when the daily dose was 300 [gamma] or more. At this dose level, approx. the equivalent of 8 [gamma] of testosterone propionate crossed to the uninjd. parabiont. Seminal vesicles and prostate glands equal in wt. to those of single normal rats were obtained in uninjd. parabionts when 1000 [gamma] of testosterone propionate were injd. into the other partner.

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