Two‐Year Changes in L ipids and Lipoproteins Associated with the Maintenance of a 5 % to 10% Reduction in Initial Weight: Some Findings and Some Questions

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Abstract
WADDEN, THOMAS A., DREW A. ANDERSON, AND GARY D. FOSTER. Two‐year changes in lipids and lipoproteins associated with the maintenance of a 5% to 10% reduction in initial weight: some findings and some questions. Obes Res. Objective This study assessed whether a 5% to 10% reduction in initial weight would be associated with as favorable long‐term (i.e., 100 weeks) changes in lipids and lipoproteins, as have been observed on a short‐term basis (i.e., 8 weeks). Research Methods and Procedures This was a prospective evaluation of 25 obese women, each of whom had lost ≥5% of initial weight during 48 weeks of treatment and had maintained a weight loss of this magnitude at 1‐year follow‐up (week 100). Lipids and lipoproteins were obtained at baseline and at weeks 8, 24, 48, and 100. All participants had a baseline total cholesterol ≥5.17 mmol/L (200 mg/dL). Results At the end of the first 8 weeks, weight fell an average of 11.7±2.8%, total cholesterol 20.6±7.5%, low‐density‐lipoprotein (LDL) cholesterol 23.0±18.1%, and triglycerides 26.0±20.1%. At week 48, weight had fallen to 20.1±7.0% below baseline, but total cholesterol and LDL cholesterol were reduced only 11.5±10.4% and 12.0±14.0% below baseline, respectively. These latter reductions were significantly (ppp10% of initial weight had significantly greater reductions in total and LDL cholesterol values than did patients who maintained losses of only 5% to 10% of initial weight. Discussion Results of this study underscore the importance of assessing long‐term changes in weight‐related health complications when patients have lost weight but are no longer dieting (and exercising) as aggressively as they did during the initial months of treatment.

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