Evaluation of anti-cardiolipin antibody and its cross-reactivity in sera of patients with lepromatous leprosy

1 June 1986

journal article
research article
Published by Springer Nature in Archives of Dermatological Research

Vol. 278 (4) , 317-319
https://doi.org/10.1007/bf00407745

Abstract

Summary Using a sensitive and modified solid-phase radioimmunoassay for detecting anti-cardiolipin antibodies, sera of 45 patients with lepromatous leprosy were examined. Nine of the 45 (20%) showed positive levels of anti-cardiolipin antibodies. Inhibition tests revealed that these antibodies significantly cross-reacted with double-stranded (ds) DNA, but not with single-stranded (ss) DNA or extractable nuclear antigens (ENA). We describe the unique pattern of antibody cross-reactivity with cardiolipin and dsDNA in sera of patients with lepromatous leprosy.

Keywords

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