Enhanced immunostimulation by novel platinum anticancer agents
- 1 April 1997
- journal article
- research article
- Published by Wolters Kluwer Health in Anti-Cancer Drugs
- Vol. 8 (4) , 323-328
- https://doi.org/10.1097/00001813-199704000-00003
Abstract
'Poly-plat', SSP and SAP are second generation analogs of cisplatin which have been shown to activate murine peritoneal macrophages in vivo and in vitro. Murine peritoneal macrophages treated with 'poly-plat', SSP or SAP (5 µg/mg) for 2 h are stimulated to form cytoplasmic extensions. Drug-treated macrophages also elicit an increase in the number of lysosomes. In addition, analysis of tissue culture supernatants shows increased levels of interleukin- 1a and tumor necrosis factor-a. These results show that 'poly-plat', SSP and SAP enhance the immune system with greater efficacy and potency than cisplatin.Keywords
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