The effect of thalidomide treatment on vascular pathology and hyperalgesia caused by chronic constriction injury of rat nerve

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Abstract
Tumor necrosis factor alpha (TNF) may be involved in the pathogenic mechanisms of neuropathic pain by affecting endothelial cells and by upregulation of receptor sensitivity in afferent nerve fibers. To test the hypothesis that TNF plays a role in the vascular changes and the pain-related be