Arf family GTP loading is activated by, and generates, positive membrane curvature
Open Access
- 12 August 2008
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 414 (2) , 189-194
- https://doi.org/10.1042/bj20081237
Abstract
Small G-proteins belonging to the Arf (ADP-ribosylation factor) family serve as regulatory proteins for numerous cellular processes through GTP-dependent recruitment of effector molecules. In the present study we demonstrate that proteins in this family regulate, and are regulated by, membrane curvature. Arf I and Arf6 were shown to load GTP in a membrane-curvature-dependent manner and stabilize, or further facilitate, changes in membrane curvature through the insertion of an amphipathic helix.Keywords
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