SERPIGINOUS CHOROIDOPATHY ASSOCIATED WITH ELEVATED FACTOR VIII-VON WILLEBRAND FACTOR ANTIGEN
- 1 January 1990
- journal article
- research article
- Published by Wolters Kluwer Health in Retina
- Vol. 10 (2) , 97-101
- https://doi.org/10.1097/00006982-199004000-00001
Abstract
Elevated Factor Vlll-von Willebrand factor antigen levels are associated with vascular endothelial injury in several disorders, including scleroderma, Raynaud's phenomenon, polymyalgia rheumatica, and temporal arteritis. Eight patients with serpiginous choroidopathy were evaluated with the use of quantitative immunoelectrophoresis for Factor Vlll-von Willebrand factor antigen. The serpiginous choroidopathy patients had a mean Factor Vlll-von Willebrand factor activity of 226 ± 47.3%, whereas a disease-free, age- and sex-matched control group had a mean activity of 107 ± 28%. These findings are statistically significant (P>0.005) and suggest that in some patients, serpiginous choroidopathy represents an occlusive vascular phenomenon that involves the choroidal circulation.Keywords
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