Activated oxygen and mammalian nitrate biosynthesis
- 1 September 1984
- journal article
- research article
- Published by Oxford University Press (OUP) in Carcinogenesis: Integrative Cancer Research
- Vol. 5 (9) , 1161-1164
- https://doi.org/10.1093/carcin/5.9.1161
Abstract
The oxidation of NH 3 to NO3 -by rat liver in vitro is described. A xanthine-xanthine oxidase reaction also oxidized NH 3 to NO 3 - when H 2 O 2 was added. An in vivo inhibitor of superoxide dismutase enhanced the in vitro liver conversion of NH 3 to NO 3 -. Thus, intracellular oxidation by activated oxygen likely represents the source of endogenously formed NO 3 - in mammals.Keywords
This publication has 4 references indexed in Scilit:
- A rapid method for estimating nitrate in biological samples using gas chromatography with a flame-ionization detector or a thermal energy analyzerFood and Chemical Toxicology, 1984
- Oxidation of ammonia and hydroxylamine to nitrate in the rat and in vitroCarcinogenesis: Integrative Cancer Research, 1984
- Nitrate formation in rats exposed to nitrogen dioxideToxicology and Applied Pharmacology, 1983
- Analysis of nitrate, nitrite, and [15N]nitrate in biological fluidsAnalytical Biochemistry, 1982