Effect of norepinephrine on intramyocardial distribution of blood flow in normal and ischemic myocardium

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Abstract
Using labelled microspheres, the effect of norepinephrine (NE) infusions (15 μg and 30 μg/min) on coronary blood flow and its intramyocardial distribution during ischemia was studied. The results reported here show that in the ischemic myocardium, the ratio of endocardial to epicardial flow was 0.67. This value became 1.0 in dogs receiving NE at a dose of 30 μg/min. Since an adrenergic discharge is known to accompany angina in man, these data suggest that an imbalance between the endocardial and epicardial blood flow might not be present in this clinical condition.