ULTRASTRUCTURAL-CHANGES IN THE EXOCRINE PANCREAS OF EXPERIMENTAL PANCREATOLITHIASIS IN DOGS

  • 1 January 1982
    • journal article
    • research article
    • Vol. 77  (7) , 498-503
Abstract
Histological changes in the pancreas at an early stage of pancreatolithiasis were observed using a canine model in which obstruction was induced by partial ligation of the major pancreatic duct. Light micrographs demonstrated pancretic lesions similar to those in humans. EM revealed dilated lumens of small ducts and degenerated ductal cells 3 mo. after the ligation. These changes became more severe and appeared more often when the period of ligation was prolonged up to 1 yr. Acinar cells demonstrated dilatation of the rough endoplasmic reticulum and the Golgi apparatus, swelling of the mitochondria and increase in the number of prezymogen granules. Microfilamentous substance appeared in markedly dilated rough endoplasmic reticulum and in the intercellular space as acinar cell lesions progressed and the basal membrane became disrupted. The substance might be involved in calculous formation, the incidence of which reached a plateau after 6 mo. of ligation, coinciding with the peak in appearance of the substance.

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