THE ASSAY OF HUMAN THYROCALCITONIN IN MICE

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Abstract
SUMMARY: A mouse assay for thyrocalcitonin using either intravenous or intraperitoneal injections is described. Responses to porcine thyroid extracts were similar to those in rats. Extracts of human thyroid glands obtained at autopsy or surgical operation caused hypocalcaemia in the mouse. The rat was less sensitive to human thyrocalcitonin. Studies on autopsy tissue showed that human thyrocalcitonin could only be detected if thyroids were removed within 12 hr. after death. Crude extracts of human thyroids were assayed in mice by intraperitoneal injection and the thyrocalcitonin content was determined in tissue obtained from patients with thyrotoxicosis or non-toxic goitre.

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