PATERNAL AGE AND DOWN SYNDROME IN BRITISH-COLUMBIA
- 1 January 1981
- journal article
- research article
- Vol. 33 (1) , 123-128
Abstract
Among Down''s syndrome cases born in 1964-1976 reported to the British Columbia Registry for Handicapped Children [Canada], the mean paternal age was about half a year greater than in the entire population of live births after controlling for maternal age, a difference significant at the 0.05 level. After adjustment for maternal age, a regression analysis was consistent with an increase of 1.024-fold for each year of paternal age. Among Down''s syndrome cases in 1952-1963, however, for which ascertainment appears to be less than complete, there was no evidence for a significant paternal age effect. The reasons for the variation between the 2 groups investigated here and the heterogeneity in results among studies of other populations are discussed.This publication has 12 references indexed in Scilit:
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