Cyclic Nucleotide Phosphodiesterase: High Activity in a Mammalian Photoreceptor
- 18 February 1972
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 175 (4023) , 757-758
- https://doi.org/10.1126/science.175.4023.757
Abstract
Purified outer segments of bovine rods exhibit phosphodiesterase activity against adenosine and guanosine cyclic 3′,5′-monophosphates (cyclic AMP and cyclic GMP). The enzyme hydrolyzed cyclic GMP more rapidly than cyclic AMP at low substrate concentrations. The presence of high phosphodiesterase activity in this highly specialized organelle suggests that this enzyme may function in control of cyclic nucleotide concentration during visual excitation or adaptation.Keywords
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