Should HIV-positive patients with lymphoma be offered stem cell transplants?
- 1 October 2003
- journal article
- review article
- Published by Springer Nature in Bone Marrow Transplantation
- Vol. 32 (8) , 741-748
- https://doi.org/10.1038/sj.bmt.1704270
Abstract
Advances in effective antiretroviral therapy for HIV infection have made high-dose therapy and autologous stem cell transplantation possible in patients with HIV-associated lymphomas. Regimen-related toxicity is not significantly increased when antiretroviral therapy is combined with high-dose chemoradiotherapy. Durable engraftment can be seen with autologous stem cell rescue. Infectious complications can be managed with a combination of surveillance and prophylaxis. Long-term remissions of these high-risk lymphomas can be achieved with this approach. This suggests that patients with HIV-associated lymphomas should be considered for autologous transplantation in a manner similar to HIV-negative lymphoma patientsKeywords
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