The Effects of Vasopressin on the Systolic Time Intervals in the Dog

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Abstract
By simultaneously recording the carotid artery pressure, an electro-cardiographic lead and the chest phonocardiogram in the anesthetized dog, the effects of vasopressin on the systolic time intervals were observed. Vasopressin administered intravenously by bolus or infusion or subcutaneously produced a prolongation of the preejection period which was ascribed to a depressed rate of development of the myocardial contractile force and to a reduction in the stroke volume. It is suggested that the noninvasive measurement of the systolic time intervals in man may be used in monitoring patients under vasopressin treatment for gastrointestinal hemorrhage.

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