OROSOMUCOID (ORM) TYPING BY ISOELECTRIC-FOCUSING - EVIDENCE FOR AN ADDITIONAL DUPLICATED ORMI LOCUS HAPLOTYPE AND CLOSE LINKAGE OF 2 ORM LOCI

  • 1 August 1988
    • journal article
    • research article
    • Vol. 43  (2) , 165-169
Abstract
Human serum orosomucoid (ORM) exhibits a high variability. Several alleles including a duplicated ORM1 gene (ORM1*2.1) have been identified at two functional ORM loci, ORM1 and ORM2. In this study a modified isoelectric focusing, in which glycerin was omitted from gels, was used to differentiate a new variant ORM1 5 from 2 3. The ORM1 5 band was always observed together with the ORM1 2 band. The simultaneous expression could be explained in terms of an additional duplicated ORM1 locus haplotype, ORM1*5.2, whose average frequency was .016 in two Japanese populations. The ORM2*6 found at a polymorphic frequency (.023) was demonstrated to be in association with ORM1*2, indicating the close proximity between ORM1 and ORM2 loci.