Scavenger receptors in neurobiology and neuropathology: Their role on microglia and other cells of the nervous system
Top Cited Papers
- 4 October 2002
- Vol. 40 (2) , 195-205
- https://doi.org/10.1002/glia.10148
Abstract
Scavenger receptor class A (SR-A, CD204), scavenger receptor-BI (SR-BI), and CD36 are cell surface proteins that mediate cell adhesion to, and endocytosis of, various native and pathologically modified substances, and participate in intracellular signaling, lipid metabolism, and host defense against bacterial pathogens. Microglia, Mato cells, astrocytes, cerebral microvascular endothelial cells, cerebral arterial smooth muscle cells, and retinal pigment epithelial cells express one or more of these SR. Expression of SR-A and SR-BI by microglia is developmentally regulated. Neonatal microglia express SR-A and SR-BI, while microglia in normal mouse and human adult brain express neither. Astrocytes in adult brain express SR-BI. In Alzheimer's disease, microglial expression of SR-A is increased. Such findings, and evidence that SR-A and SR-BI mediate adhesion and endocytosis of fibrillar beta-amyloid by microglia and astrocytes, respectively, and that SR-A, SR-BI, and CD36 participate in secretion of reactive oxygen species by microglia, suggest roles for these receptors in homeostasis and neuropathology.Keywords
This publication has 86 references indexed in Scilit:
- CD36: a class B scavenger receptor involved in angiogenesis, atherosclerosis, inflammation, and lipid metabolismJournal of Clinical Investigation, 2001
- Scavenger Receptor Class B Type I-mediated Reverse Cholesterol Transport Is Inhibited by Advanced Glycation End ProductsJournal of Biological Chemistry, 2001
- Amyloid β protein activates PKC-δ and induces translocation of myristoylated alanine-rich C kinase substrate (MARCKS) in microgliaNeurochemistry International, 2001
- Oxidized LDL–Induced NF-κB Activation and Subsequent Expression of Proinflammatory Genes Are Defective in Monocyte-Derived Macrophages From CD36-Deficient PatientsArteriosclerosis, Thrombosis, and Vascular Biology, 2000
- Apolipoprotein E, Smooth Muscle Cells and the Pathogenesis of Cerebral Amyloid Angiopathy: the Potential Role of Impaired Cerebrovascular Aβ ClearanceAnnals of the New York Academy of Sciences, 2000
- Lipopolysaccharide Inhibits the Expression of the Scavenger Receptor Cla-1 in Human Monocytes and MacrophagesBiochemical and Biophysical Research Communications, 1999
- Complementary Roles for Scavenger Receptor A and CD36 of Human Monocyte–derived Macrophages in Adhesion to Surfaces Coated with Oxidized Low-Density Lipoproteins and in Secretion of H2O2The Journal of Experimental Medicine, 1998
- Immunohistochemical Evidence for a Macrophage Scavenger Receptor in Mato Cells and Reactive Microglia of Ischemia and Alzheimer's DiseaseBiochemical and Biophysical Research Communications, 1998
- High‐Density Lipoprotein Aggregated by Oxidation Induces Degeneration of Neuronal CellsJournal of Neurochemistry, 1997
- Upregulation of the macrophage scavenger receptor in response to different forms of injury in the CNSJournal of Neurocytology, 1994