DOPAMINE REGULATES CANINE PLASMA β-ENDORPHIN-IMMUNOREACTIVITY LEVELS
- 1 May 1982
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 110 (5) , 1828-1830
- https://doi.org/10.1210/endo-110-5-1828
Abstract
Intravenous administration of the dopamine antagonists domperidone and metoclopramide elevates canine plasma β-endorphin immunoreactivity. Pretreatment with dopamine, but not dexamethasone, inhibits this effect. Sephadex G-50 chromatography shows that this response is due to β-endorphin-like peptides, not β-lipotropin. These findings indicate that pituitary β-endorphin secretion is tonically inhibited by dopamine and suggest that the intermediate lobe is the source of this secretion.Keywords
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