Activation of Plasma Thromboplastinogen and Evidence of an Inhibitor.

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Abstract
The first step in coagulation is the conversion of an inactive plasmatic factor, thromboplastinogen, to active thromboplastin by a platelet factor. The reaction can be easily studied by means of the prothrombin consumption test, which consists in determining the amt. of prothrombin present before and after coagulation (in serum). Evidence of this theory is given together with the demonstration that platelets from hemo-philic blood react as well as those of normal blood. Presence of a factor which inhibits the activation of thromboplastinogen occurs in the blood of a patient who has an acquired hemophilia-like condition. It is then concluded that a thromboplastin deficiency may arise either from a lack of thromboplastinogen in the plasma or from the presence of an agent which inhibits the platelet factor. A third possible cause is postulated, namely, a lack of the platelet factor. All 3 conditions are characterized by a markedly incomplete conversion of prothrombin.

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