Mechanisms of cycloheximide‐induced apoptosis in liver cells
- 13 October 1997
- journal article
- Published by Wiley in FEBS Letters
- Vol. 416 (1) , 113-116
- https://doi.org/10.1016/s0014-5793(97)01161-7
Abstract
Cycloheximide in sublethal doses caused apoptosis in liver cells in vivo, inducing c‐myc, c‐fos, c‐jun and p53 genes and accumulation of sphingosine, a toxic product of the sphingomyelin cycle. These data support the hypothesis that continuous synthesis of labile protective proteins is required to restrain apoptosis in liver; sphingosine might be important in mediating cycloheximide‐induced apoptosis as an endogenous modulator of protein kinase C activity.Keywords
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