Transdermal Testosterone

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Abstract
▴ Nightly application of testosterone transdermal (TTD) system to nonscrotal sites in men with hypogonadism results in a 24-hour serum testosterone concentration profile which mimics the circadian pattern observed in healthy young men. ▴ The system also normalises dihydrotestosterone/testosterone and estradiol/testosterone ratios and reduces luteinising hormone levels towards the normal range. ▴ A multicentre, open-label study demonstrated that nocturnal erectile response and overall sexual function improved during 12 months’ treatment with the TTD system (5 mg/day) in men with hypogonadism. Individual variables of sexual desire, arousal, frequency of sexual activity, orgasm and satisfaction also improved. ▴ The TTD system is well tolerated, with application site reactions such as pruritus, burn-like blisters and erythema being the most commonly reported events. ▴ Prostate-specific antigen levels and prostate volume remain in the normal range during long term treatment.