A Facile One-Pot Synthesis of Polyfunctionalized 2-Unsubstituted Benzo[b]furans
- 1 January 1993
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1993 (04) , 269-270
- https://doi.org/10.1055/s-1993-22663
Abstract
A facile one-pot synthesis of 2-unsubstituted highly functionalized benzo[b]furans is reported. The synthesis includes the coupling of an iodophenol derivative with (trimethylsilyl)acetylene, catalyzed by a Pd(0)/Cu(I) system, and a regioselective cyclizationdeprotection step mediated by TMG (1,1,3,3-tetramethylguanidine) and SiO2. Selective reductions then afford the dihydro analogues.Keywords
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