Effect of Experimental Cryptorchidism on the Histochemically Demonstrable Dehydrogenases of the Rat Testis

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Abstract
Rats were made unilaterally cryptorchid. Dehydrogenase (tetrazolium reductase) activities of the testis were observed from 2 to 64 days thereafter with respect to the following substrates: succinate, reduced di- and triphosphopyridine nucleotides (DPNH and TPNH), lactate, β-hydroxybutyrate, glucose-6-phosphate and dehydroepiandrosterone. In the interstitial cells, the activities with, respect to DPNH, TPNH and β-hydroxybutyrate decreased, that toward succinate increased, and those toward glucoses-phosphate and lactate remained essentially unchanged. Steroid-3β-ol dehydrogenase activity disappeared almost completely. In the atrophied seminiferous tubules, all the enzyme activities studied increased except with respect to succinate, which rapidly decreased postoperatively. The changes observed suggest a decreased hormone production in the unilaterally cryptorchid testis. (Endocrinology74: 44, 1964)