Blockade by anti-glucocorticoids, actinomycin D and cycloheximide of the anti-inflammatory action of some Kampohozai (Chinese traditional medicines) against serotonin.

Publisher Website
Google Scholar
Abstract
Blockade by anti-glucocorticoids, progesterone and 17 .alpha.-methyltestosterone, a mRNA synthesis inhibitor, actinomycin D, and a protein synthesis inhibitor, cycloheximide, of the anti-exudative action of 5 kinds of Kampohozai (Daisaikoto, Shosaikoto, Saikokeishito, Daiobotanpito and Tokakujokito) were studied to investigate mode of the anti-inflammatory action of those Kampohozai. The inflammatory lesion was provoked by injection of serotonin (0.3 .mu.g) in the Tyrode solution (5 .mu.l) in subplantar region of the hind paw of mice. The above anti-glucocorticoids and the mRNA and protein synthesis inhibitors suppressed the anti-inflammatory effects of Daisaikoto and Shosaikoto dose-dependently. The action of Saikokeishito was suppressed weakly by treatment with progesterone or 17.alpha.-methyltestosterone, but not blocked by treatment with actinomycin D or cycloheximide. Daiobotanpito and Tokakujokito were not blocked by treatment with those 4 inhibitors. These results suggest that the mechanism of anti-inflammatory action of Daisaikoto and Shosaikoto is similar to that of glucocorticoid but Diaobtanpito and Tokakujokito exert anti-inflammatory effects through some other mechanisms.

This publication has 1 reference indexed in Scilit: