Effect of clonidine on the noradrenergic cyclic AMP generating system in the limbic forebrain and on medial forebrain bundle self-stimulation behavior
- 1 November 1977
- journal article
- Published by Springer Nature in Cellular and Molecular Life Sciences
- Vol. 33 (11) , 1490-1491
- https://doi.org/10.1007/bf01918827
Abstract
The present results show that clonidine does not mimic the agonist action of norepinephrine (NE) on the noradrenergic cyclic AMP generating system of the limbic forebrain, but antagonizes the stimulatory effect of NE while not influencing the action of isoprenaline. In self-stimulation behavior, clonidine decreases responding and blocks the facilitation caused by d-amphetamine.Keywords
This publication has 16 references indexed in Scilit:
- ADAPTIVE MECHANISMS OF THE NORADRENERGIC CYCLIC AMP GENERATING SYSTEM IN THE LIMBIC FOREBRAIN OF THE RAT: ADAPTATION TO PERSISTENT CHANGES IN THE AVAILABILITY OF NOREPINEPHRINE (NE)1,2Journal of Neurochemistry, 1976
- The noradrenergic cyclic AMP generating system in the limbic forebrain: Pharmacological characterization in vitro and possible role of limbic noradrenergic mechanisms in the mode of action of antipsychoticsEuropean Journal of Pharmacology, 1976
- Amphetamine and the reward system: Evidence for tolerance and post-drug depressionPsychopharmacology, 1976
- Inhibition of both noradrenergic and serotonergic neurons in brain by the α-adrenergic agonist clonidineBrain Research, 1975
- Self-stimulation reward pathways: Norepinephrine vs dopamineJournal of Psychiatric Research, 1974
- Involvement of α-receptors in clonidine-induced inhibition of transmitter release from central monoamine neuronesNeuropharmacology, 1973
- Inhibition of adrenergic neurotransmission by clonidine: An action on prejunctional α-receptorsNeuropharmacology, 1973
- Pharmacological studies on the hypotensive effects of clonidineEuropean Journal of Pharmacology, 1971
- A Protein Binding Assay for Adenosine 3′:5′-Cyclic MonophosphateProceedings of the National Academy of Sciences, 1970
- Evidence for a central noradrenaline receptor stimulation by clonidineLife Sciences, 1970