Experimental Intraabdominal Candidiasis: Macroscopic, Microscopic and Cultural Natural History

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Abstract
A rabbit model for intraabdominal candidiasis was developed by the i.p. injection of Candida albicans. The most reliable early predictor of induction of disease was positive paracentesis cultures for C. albicans during the 1st wk post-inoculation (p.i.). Cultures of mesenteric and renal abscesses were mean log 6.20 and 3.18 colony-forming units (CFU)/tissue, respectively, 1 wk p.i., and remained positive for the 21 day p.i. period. Incidence of hematogenous dissemination, judged by chorioretinal cultures, was 69%. Histopathology of involved organs demonstrated suppurative abscesses at 1 wk p.i., lesions became more granulomatous at 2 and 3 wk p.i.