Stereospecificity of allergic contact dermatitis (ACD) to enantiomers
- 1 December 1982
- journal article
- research article
- Published by Springer Nature in Archives of Dermatological Research
- Vol. 274 (3-4) , 277-281
- https://doi.org/10.1007/bf00403730
Abstract
Guinea pigs were sensitized to polygodial 1, a natural sesquiterpene dialdehyde, using intradermal injections in Freund's complete adjuvant. Cross-reactions with a (±)-mixture of warburganal and (-)-warburganal 2 (a natural hydroxylated derivative of polygodial) showed a high specificity of the allergic response since the (-)-pseudoenantiomer (having the same configuration as the primary sensitizer) gave a stronger skin reaction than the racemic mixture.This publication has 9 references indexed in Scilit:
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