Liquid chromatography with an inductively coupled plasma mass spectrometric detector for simultaneous determination of gold drug metabolites and related metals in human blood
- 1 January 1989
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of Analytical Atomic Spectrometry
- Vol. 4 (8) , 767-771
- https://doi.org/10.1039/ja9890400767
Abstract
The use of inductively coupled plasma mass spectrometry (ICP-MS) for the analysis of blood samples from rheumatoid arthritis patients on gold drug therapy is demonstrated. Flow injection allows the determination of multiple metal ions (Au, Zn and Cu) in a single injection with detection limits that are more than adequate for the analysis. Matrix effects are significant with these samples. Chromatography is also possible with ICP-MS as the detector. Examples are given of high-performance liquid chromatography of patient blood samples using size-exclusion and weak anion-exchange columns.Keywords
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