Xanthogranulomatous cholecystitis

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Abstract
(Fibro)xanthogranulomatous cholecystitis is an uncommon lesion which may form a tumor-like mass in inflamed gallbladders. A few cases have been mistaken for neoplasms. In a review of 40 cases there were 26 associated with gallstones and 9 with tumors of the biliary tract, 6 of which also had stones. Grossly, the lesions are usually soft, yellow to brown and measure up to 2.5 cm. Microscopically, there are varying amounts of inflammation, xanthoma-like foam cells and scarring. The lesions appear to result from ruptured Rokitansky-Aschoff sinuses with intramural extravasation of bile and subsequent xanthogranulomatous reaction.

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