A CORRELATION BETWEEN HLA-C MATCHING AND DONOR ANTIRECIPIENT CTL PRECURSOR FREQUENCY IN BONE MARROW TRANSPLANTATION
- 15 May 1996
- journal article
- research article
- Published by Wolters Kluwer Health in Transplantation
- Vol. 61 (9) , 1420-1423
- https://doi.org/10.1097/00007890-199605150-00027
Abstract
A newly developed, reliable, DNA-based method for typing for alleles of the HLA-C locus has been applied in the context of unrelated, volunteer donors for bone marrow transplantation. Some donors matched for HLA-A, -B, -DR, and -DQ have been found to generate in vitro high frequencies of CTL reactive with the recipient's cells. Here we demonstrate that there is a highly significant correlation of the frequencies of CTL precursors and incompatibility at the HLA-C locus. These data indicate that HLA-C locus incompatibility should be avoided in unrelated donor bone marrow transplantation.Keywords
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