A Novel Use for Drotrecogin Alfa (Activated): Successful Treatment of Septic Shock Associated with Coccidioidomycosis
Open Access
- 1 December 2004
- journal article
- case report
- Published by Oxford University Press (OUP) in Clinical Infectious Diseases
- Vol. 39 (11) , e122-e123
- https://doi.org/10.1086/425918
Abstract
We present 2 cases of septic shock associated with coccidioidomycosis that were successfully treated with drotrecogin alfa (activated) in combination with antifungal agents. The favorable outcomes, in light of the high mortality usually associated with this condition, suggest that drotrecogin alfa (activated) may be a valuable adjunct for treating septic shock due to endemic mycoses.Keywords
This publication has 5 references indexed in Scilit:
- Systemic Host Responses in Severe Sepsis Analyzed by Causative Microorganism and Treatment Effects of Drotrecogin Alfa (Activated)Clinical Infectious Diseases, 2003
- Efficacy and Safety of Recombinant Human Activated Protein C for Severe SepsisNew England Journal of Medicine, 2001
- Multi‐organ failure caused by reactivated coccidioidomycosis without dissemination in a patient with renal transplantationRespirology, 2000
- Septic shock in coccidioidomycosisCritical Care Medicine, 1998
- Acute pulmonary coccidioidomycosis mimicking bacterial pneumonia and septic shock: A report of two casesThe American Journal of Medicine, 1993