Colchicine resistance in human cell lines. Pleiotropic phenotype and decreased membrane permeability
- 1 August 1982
- journal article
- research article
- Published by Springer Nature in Human Genetics
- Vol. 61 (1) , 73-75
- https://doi.org/10.1007/bf00291339
Abstract
Colchicine-resistant human cells were initially observed in patients exhibiting C-anaphases or tetraploidy in lymphocyte cultures. Cell lines established from these patients displayed cross-resistances to daunomycin, emetine, vinblastine, and vincristine and collateral sensitivity to Xylocaine, showing a pleiotropic phenotype similar to that described in permeability mutants in CHO cells. 3H colchicine uptake and binding assays confirmed a decreased permeability to the drug.Keywords
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