Sensitivity of Bloom's syndrome lymphocytes to ethyl methanesulfonate
- 1 January 1979
- journal article
- research article
- Published by Springer Nature in Human Genetics
- Vol. 50 (2) , 151-156
- https://doi.org/10.1007/bf00390236
Abstract
Ethyl methanesulfonate induced several times as many sister chromatid exchanges (SCEs) in lymphocytes from individuals affected with Bloom's syndrome as in lymphocytes from controls or heterozygotes. In cultures of cells from an individual with Bloom's syndrome who had two populations of lymphocytes circulating in his blood—‘low’ cells having normal spontaneous frequencies of SCEs and ‘high’ cells having elevated frequencies—only the high cells showed the increased sensitivity to ethyl methanesulfonate.This publication has 14 references indexed in Scilit:
- Effect of cocultivation on sister chromatid exchange frequencies in Bloom's syndrome and normal fibroblast cellsNature, 1978
- Effects of mitomycin C on sister chromatid exchange in normal and bloom's syndrome cellsMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1978
- Repair deficient human disorders and cancerNature, 1978
- Chromosome aberrations and unscheduled DNA synthesis in X- and UV-irradiated lymphocytes from a boy with Bloom’s syndrome and a man with xeroderma pigmentosumCytogenetic and Genome Research, 1977
- Bloom's syndrome. V. Surveillance for cancer in affected familiesClinical Genetics, 1977
- Ultraviolet light sensitivity and delayed DNA-chain maturation in Bloom's syndrome fibroblastsNature, 1977
- The production of micronuclei from chromosome aberrations in irradiated cultures of human lymphocytesMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1976
- New Giemsa method for the differential staining of sister chromatidsNature, 1974
- Bloom's syndrome. III. Analysis of the chromosome aberration characteristic of this disorderChromosoma, 1974
- DNA Damage and Repair in Light-Sensitive Human Skin DiseaseJournal of Investigative Dermatology, 1970