Correlation of CD4 + T-Cell Counts Estimated by an Immunocapture Technique (Capcellia) with Viral Loads in Human Immunodeficiency Virus-Seropositive Individuals
- 1 November 2001
- journal article
- research article
- Published by American Society for Microbiology in Clinical and Diagnostic Laboratory Immunology
- Vol. 8 (6) , 1286-8
- https://doi.org/10.1128/cdli.8.6.1286-1288.2001
Abstract
As antiretroviral therapy becomes more affordable, valid, reliable, and inexpensive laboratory tests are also needed to monitor the progression of disease in people with human immunodeficiency virus (HIV) infection. The CD4 + T-cell counts estimated by Capcellia, an immunocapture method, and flow cytometry were compared and were correlated with HIV type 1 (HIV-1) load. There was a significant negative correlation between the HIV-1 load and CD4 + T-cell counts estimated by flow cytometry ( r = −0.63, P = + T-cell counts estimated by Capcellia ( r = −0.61, P = <0.001). Capcellia is a cost-effective, user-friendly assay that correlated well with HIV-1 load determinations for individuals both with and without treatment.Keywords
This publication has 12 references indexed in Scilit:
- Comparative Assessment of Five Alternative Methods for CD4+ T-Lymphocyte Enumeration for Implementation in Developing CountriesJAIDS Journal of Acquired Immune Deficiency Syndromes, 2001
- Comparative Assessment of Five Alternative Methods for CD4+ T-Lymphocyte Enumeration for Implementation in Developing CountriesJAIDS Journal of Acquired Immune Deficiency Syndromes, 2001
- Peripheral CD4+/CD8+ T-lymphocyte counts estimated by an immunocapture method in the normal healthy south Indian adults and HIV seropositive individualsJournal of Clinical Virology, 2000
- Human Immunodeficiency Virus Type 1 p24 Concentration Measured by Boosted ELISA of Heat‐Denatured Plasma Correlates with Decline in CD4 Cells, Progression to AIDS, and Survival: Comparison with Viral RNA MeasurementThe Journal of Infectious Diseases, 2000
- Evaluation of a quantitative determination of CD4 and CD8 molecules as an alternative to CD4+and CD8+T lymphocyte counts in AfricansTropical Medicine & International Health, 1999
- Whole blood capcellia CD4/CD8 immunoassay for enumeration of CD4+ and CD8+ peripheral T lymphocytes.1999
- Prognostic significance of plasma markers of immune activation, HIV viral load and CD4 T-cell measurementsAIDS, 1998
- Viral load in asymptomatic patients with CD4+ lymphocyte counts above 500 × 106/lAIDS, 1997
- 1997 revised guidelines for performing CD4+ T-cell determinations in persons infected with human immunodeficiency virus (HIV). Centers for Disease Control and Prevention.1997
- Quantitative determination of CD4/CD8 molecules by a cell marker ELISA.1994