Metabolic Reduction of 1-(p-Acetylbenzenesulfonyl)-3-cyclohexylurea (Acetohexamide) in Different Species
- 1 July 1961
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 107 (3) , 583-585
- https://doi.org/10.3181/00379727-107-26694
Abstract
Metabolism of acetohexamide was investigated in dogs, rabbits, rats, and man. Trace amounts of unchanged drug were found in the urine of dogs and man. All species excreted the reduced form, 1-(p-a-hydroxy-ethyi-benezenesulfonyl)-3-cyclohexylurea. From the urine of dog, rabbit, and man 49-59% of orally administered drug was recovered as metabolite, but only 18% from the urine of the rat. Chromatograms of rat urine revealed no other metabolites.Keywords
This publication has 1 reference indexed in Scilit:
- Urinary Metabolites of Chlorpropamide in Dogs, Rabbits, and Man.Experimental Biology and Medicine, 1959