Comparative Antibacterial Activities of New β-Lactam Antibiotics against Pseudomonas aeruginosa

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Abstract
In vitro activity of 9 new cephalosporins and pencillins was determined against 417 isolates of P. aeruginosa. Carbenicillin, ticarcillin, gentamicin, tobramycin and netilmicin were also included in the study. Imipenem showed highest activity. More than 90% of the isolates were susceptible to ticarcillin, piperacillin, azlocillin, cefoperazone, cefsoludin and to tobramycin. Isolates (57) included in the study were resistant to gentamicin (MIC [minimal inhibitory concentration] > 4 mg/l); of these, none were resistant to imipenem, and > 80% were susceptible to piperacillin, azlocillin, cefoperazone and cefsulofin. [The other antibiotics tested were cefotaxime, latamoxef, mezlocillin and ceftriaxone.].