Synthesis and Anticonvulsant Activity of New Dibenzo[1,2]thiazepine S,S‐Dioxides
- 1 January 1994
- journal article
- research article
- Published by Wiley in Archiv der Pharmazie
- Vol. 327 (3) , 157-161
- https://doi.org/10.1002/ardp.19943270306
Abstract
A new series of 11‐substituted 6,11‐dihydro‐6‐methyl‐dibenzo[c,f]‐[1,2]thiazepine S,S‐dioxides was synthesized. Some of the components show significant anticonvulsant activity in the MES, pentetrazol and strychnine tests. The more active compounds are devoid of neurotoxic effects.Keywords
This publication has 5 references indexed in Scilit:
- Alkoxy-11 dibenzo[b,e]azépinones-6 à activité anti-convulsivanteEuropean Journal of Medicinal Chemistry, 1988
- Antiepileptic Drug Development: II. Anticonvulsant Drug ScreeningEpilepsia, 1978
- Care of the Mentally SickBMJ, 1972
- Comprehensive observational assessment: Ia. A systematic, quantitative procedure for assessing the behavioral and physiologic state of the mousePsychopharmacology, 1968
- Hydride Transfer Mechanisms in Strongly Acid Media. The Reduction of Carbonium Ions by Alcohols and an Evaluation of the Basic Strength of Isopropyl AlcoholJournal of the American Chemical Society, 1956