Preferential Crystallization of 2-Amino-2-phenylethanol and Its Application as a Resolving Agent

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Abstract
(±)-2-Amino-2-phenylethanol (phenylglycinol) prepared from (±)-2-amino-2-phenylacetic acid (Dl-phenylglycine) by lithium aluminium hydride reduction was efficiently resolved into a pair of optically active forms by preferential crystallization. The optically active amino alcohol was successfully applied as a basic resolving agent to the resolution of tartaric acid, 2-hydroxy-2-phenylpropionic acid, 2-hydroxy-3-phenylpropionic acid, 2-phenylpropionic acid, and 2-phenyl-2-ureidoacetic acid.

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