MAL64 c is a global regulator of ?-glucoside fermentation: identification of a new gene involved in melezitose fermentation

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Abstract
Maltase constitutive mutants at the MAL6 locus have been mapped to the newly identified regulatory gene MAL64 c. We show here that MAL64 c has in addition pleiotropic effects on sugar fermentation: MAL64 c strains constitutively synthesize an α-methylglucosidase and can complement a new gene, MTP1, for the fermentation of melezitose and α-methylglucoside. MTP1, maps near MAL1, and either encodes a permease which transports melezitose, α-methylglucoside, and maltose or regulates the activity of such a permease. This work shows that MAL64 c, a trans-acting regulatory gene, is a global regulatory gene affecting several different pathways of α-glucoside metabolism.