A novel mode of FoxM1 regulation: Positive auto-regulatory loop
- 15 June 2009
- journal article
- Published by Taylor & Francis in Cell Cycle
- Vol. 8 (12) , 1966-1967
- https://doi.org/10.4161/cc.8.12.8708
Abstract
Oncogenic transcription factor FoxM1 represents an attractive therapeutic target in the fight against cancer, because it is overexpressed in a majority of human tumors. Previously, we identified the thiazole antibiotics as potent inhibitors of FoxM1. Surprisingly, investigation of the mechanism of action of FoxM1 inhibitors revealed a novel mode of positive auto-regulation of FoxM1.Keywords
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