Varicella Vaccine — The First Six Years

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Abstract
The live attenuated varicella vaccine is the only vaccine licensed for the prevention of a disease caused by a human herpesvirus. The origin of the vaccine can be traced back to 1952, when Weller and Stoddard recovered varicella–zoster virus by cell culture and reported the first successful propagation of a herpesvirus in vitro.1 In 1974, Takahashi and colleagues attenuated the wild-type Oka strain by serial passage in guinea-pig and human cells, while preserving its immunogenicity after subcutaneous inoculation.2 Clinical trials of varicella vaccine were initiated in the United States in 1980, leading to approval by the Food and Drug Administration . . .