Free radical chain oxidation and hemolysis of erythrocytes by molecular oxygen and their inhibition by vitamin E.
- 1 January 1986
- journal article
- research article
- Published by Center for Academic Publications Japan in Journal of Nutritional Science and Vitaminology
- Vol. 32 (5) , 475-479
- https://doi.org/10.3177/jnsv.32.475
Abstract
Erythrocytes of vitamin E-deficient rats and normal rats were oxidized at 37.degree. C by molecular oxygen using a free radical initiator. The erythrocytes were oxidized by a free radical chain mechanism with kinetic chain length considerably larger than 1 and resulted in hemolysis. Vitamin E suppressed both oxidation and hemolysis, but the extent of hemolysis was determined primarily by the extent of oxidation independent of the presence or absence of vitamin E.This publication has 4 references indexed in Scilit:
- Oxidation of biological membranes and its inhibition. Free radical chain oxidation of erythrocyte ghost membranes by oxygenBiochimica et Biophysica Acta (BBA) - Biomembranes, 1985
- Inhibition of oxidation of methyl linoleate in solution by vitamin E and vitamin C.Journal of Biological Chemistry, 1984
- Autoxidation of biological molecules. 2. Autoxidation of a model membrane. Comparison of the autoxidation of egg lecithin phosphatidylcholine in water and in chlorobenzeneJournal of the American Chemical Society, 1981
- Changes of alpha-tocopherol levels in red blood cells and plasma with respect to hemolysis induced by dialuric acid in vitamin E-deficient rats.Journal of Nutritional Science and Vitaminology, 1981