From Aziridines to Oxazolines and Thiazolines: The Heterocyclic Route to Thiangazole
- 1 January 1997
- journal article
- account
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1 (01) , 1-10
- https://doi.org/10.1055/s-1997-681
Abstract
Since its isolation in 1991, the polyazole natural product thiangazole has become a popular target for total synthesis due to its challenging array of heterocyclic segments and its reported potent antiviral activity. The synthetic activity toward thiangazole is reviewed and a novel approach that takes advantage or aziridine and oxazoline intermediates en route to thiazolines is presented.Keywords
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