Identification of Differentially Expressed Proteins in Experimental Autoimmune Encephalomyelitis (EAE) by Proteomic Analysis of the Spinal Cord
- 16 June 2007
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Proteome Research
- Vol. 6 (7) , 2565-2575
- https://doi.org/10.1021/pr070012k
Abstract
The present study used isobaric tags for relative and absolute quantitation (iTRAQ) to identify novel targets in experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis. The expression of 41 proteins was significantly altered in the inflamed spinal cord. Twenty of these are implicated in EAE for the first time and many have previously been shown to play a role in antigen processing, inflammation, neuroprotection, or neurodegeneration. Keywords: EAE • multiple sclerosis • iTRAQ • mass spectrometry • spinal cordKeywords
This publication has 85 references indexed in Scilit:
- A multiplexed proteomics approach to differentiate neurite outgrowth patternsJournal of Neuroscience Methods, 2006
- Optimized proteomic analysis of a mouse model of cerebellar dysfunction using amine-specific isobaric tagsProteomics, 2006
- Analysis of the defence phosphoproteome of Arabidopsis thaliana using differential mass taggingProteomics, 2006
- Hepatoma‐derived growth factor, a new trophic factor for motor neurons, is up‐regulated in the spinal cord of PQBP‐1 transgenic mice before onset of degenerationJournal of Neurochemistry, 2006
- Temporal pattern of plasma membrane calcium ATPase 2 expression in the spinal cord correlates with the course of clinical symptoms in two rodent models of autoimmune encephalomyelitisEuropean Journal of Neuroscience, 2005
- Multiplexed Protein Quantitation in Saccharomyces cerevisiae Using Amine-reactive Isobaric Tagging ReagentsMolecular & Cellular Proteomics, 2004
- Hepatoma-derived Growth Factor Is a Neurotrophic Factor Harbored in the NucleusJournal of Biological Chemistry, 2004
- Accelerated evolution of brain atrophy and “black holes” in MS patients with APOE‐ε4Annals of Neurology, 2004
- Annexin II/p11 is up-regulated in Purkinje cells in EAE and MSNeuroReport, 2003
- Lipid peroxidation products and antioxidant proteins in plasma and cerebrospinal fluid from multiple sclerosis patientsNeurochemical Research, 1985