PRIMARY NEOPLASTIC TRANSFORMATION INVIVO OF XENOGENEIC SKIN-GRAFTS ON NUDE-MICE

  • 1 January 1979
    • journal article
    • research article
    • Vol. 39  (1) , 273-276
Abstract
Rabbit skin was infected with Shope papilloma virus and grafted orthotopically to nude mice. Typical Shope rabbit papillomas developed in most grafts, but similarly treated nude mouse skin grafts were not altered. Xenogeneic tissues apparently retained susceptibility to oncogenic agents after transplantation to nude mice. It should be feasible to study carcinogenesis of human tissues in this system.

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