STUDIES IN MUCOUS MEMBRANE HYPERSENSITIVENESS. IV. THE ALLERGIC REACTION IN THE PASSIVELY SENSITIZED MUCOUS MEMBRANES OF THE ILEUM AND COLON IN HUMANS

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Abstract
The allergic reactions of the passively locally sensitized mucous membranes of the ileum and colon were studied in 2 non-atopic individuals, one of whom had an ileocolostomy, the other a colostomy. Sites on the exposed mucous membranes of the ileum and colon were sensitized to peanut protein by the intramucosal injection of 0.05 cc. of human serum containing a high titer of atopic reagins for peanut. A cutaneous site on the arm of each subject was also sensitized. 24-96 hrs. after sensitization, allergic reactions were induced at the sensitized mucous membrane sites by the administration of the peanut antigen in the form of a "milk" made by dissolving 10 g. of raw ground peanuts in 30 cc. of tap water. The allergic reactions at the sensitized mucous membrane sites were characterized by edema, hyperemia, and increased secretion. They appeared within 5-8 min. after administration of the test meal, and usually preceded the cutaneous reactions by several min. Eosinophiles were not detected in the mucous secretion produced by the allergic reaction.

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