LIBERATION OF PEROXIDE IN THE BREAKDOWN OF ISONIAZID
- 1 January 1956
- journal article
- research article
- Published by Elsevier
- Vol. 73 (5) , 779-780
- https://doi.org/10.1164/artpd.1956.73.5.779
Abstract
When 100 [mu]g/ml isoniazid were incubated in phosphate buffer containing citrate and manganese, at 37 C, 59 [mu]g of isoniazid were destroyed in 18 hours. Peroxide was liberated during the breakdown of isoniazid. Peroxide formed by the breakdown of isoniazid within the myco-bacterial cell may be responsible for the action of isoniazid.Keywords
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