Teratogenicity and Embryotoxicity of Thalidomide and 3-Aza-Thalidomide in Mice

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Abstract
The molecules of thalidomide (I) and 3-azathalidomide (II) have the characteristic aromatic six-membered ring 1,2-dicarboximide structure which is regarded as necessary for effecting teratogenicity. Pregnant SWS mice were given single i.p. injections of I and II on day 9 of gestation. A mixture of physiological saline and Tween 20 (3:1) was used as solvent. II showed a much higher teratogenic and embryotoxic effect than I. This variation is assumed to be caused by a different ability of the two substances to intercalate between base pairs of the double helix of DNA.

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