THE SECRETION OF AN ANTIDIURETIC SUBSTANCE INTO THE CIRCULATION OF RATS EXPOSED TO NOXIOUS STIMULI12

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Abstract
Exposure to a physical or emotional stimulus which is noxious to animal or man results in an inhibition of the diuresis induced by the ingestion of water (Pickford, 1945; Verney, 1947; Kelsall 1949). This antidiuretic response to a stressful stimulus is diminished in the absence of the neurohypophysis (O’Conner and Verney, 1942). Consequently, it has been postulated that the antidiuretic response is dependent upon the activation of the neurohypophysis and the release of an “anti-diuretic hormone“ into the circulation. Direct evidence that an increase in the antidiuretic activity of the blood occurs when an animal is exposed to a noxious stimulus is not available. With the development of a relatively simple, sensitive and precise procedure for the assay of antidiuretic substances (ADS) in the blood plasma (Stein, Jinks, and Mirsky, 1952), it became possible to determine the activity of the plasma from rats exposed to noxious stimuli.

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