Nerve Terminal Excitability and Neuromuscular Transmission inT(X;Y)V7andShakerMutants ofDrosophila Melanogaster
- 1 January 1991
- journal article
- research article
- Published by Taylor & Francis in Journal of Neurogenetics
- Vol. 7 (2-3) , 75-84
- https://doi.org/10.3109/01677069109066212
Abstract
We investigated the neuromuscular transmission in relation with genetic neuronal excitability changes in mutants T(X;Y)V7 and ShKS133 of Drosophila. These mutations affect two different genes belonging to the Shaker gene complex which encode different yet functionally related proteins. Experiments were performed on neuromuscular junctions from Drosophila larvae by recording pre- and postsynatic membrane currents using external electrodes. It was found that the neuromuscular electrophysiological phenotype of T(X;Y)V7 is caused by presynaptic membrane hyperexcitability probably in relation with a Ca2+-dependent down regulation of voltage dependent K channels. By contrast, the ShKS133 phenotype can be explained solely by action potential widening due to the absence of type-A K channels.Keywords
This publication has 24 references indexed in Scilit:
- The roles of potassium currents in Drosophila flight musclesJournal of Neuroscience, 1988
- Neurogenetic Analysis of Potassium Currents in Drosophila: Synergistic Effects on Neuromuscular Transmission in Double MutantsJournal of Neurogenetics, 1983
- Presynaptic currents in mouse motor endingsThe Journal of Physiology, 1982
- Transmission by presynaptic spike-like depolarization in the squid giant synapse.Proceedings of the National Academy of Sciences, 1982
- Two Mutations of synaptic transmission in DrosophilaProceedings of the Royal Society of London. B. Biological Sciences, 1977
- Properties of the larval neuromuscular junction in Drosophila melanogaster.The Journal of Physiology, 1976
- Modification of transmitter release by ions which prolong the presynaptic action potentialThe Journal of Physiology, 1970
- Patterned Neural Activity of a Mutant Drosophila melanogasterProceedings of the National Academy of Sciences, 1970
- Propagation of electric activity in motor nerve terminalsProceedings of the Royal Society of London. B. Biological Sciences, 1965
- The mechanism of presynaptic inhibition at the crayfish neuromuscular junctionPflügers Archiv - European Journal of Physiology, 1965